Fig. 6: The YTHDC2-ATF3 axis regulates MYC in the tumor-infiltrating macrophages of TNBC. | npj Precision Oncology

Fig. 6: The YTHDC2-ATF3 axis regulates MYC in the tumor-infiltrating macrophages of TNBC.

From: YTHDC2 manipulates anti-tumoral macrophage polarization and predicts favorable outcomes in triple negative breast cancer

Fig. 6

a Hubba analysis using the Degree algorithm in Cytoscape to identify hub genes using 144 genes from the Venn diagram intersection. b STRING analysis of the hub genes identified by the Degree algorithm in Cytoscape using 144 genes from Venn diagram intersection. c–e GSEA (hypeR) on genes regulated by MYC, with enrichment analysis for KEGG (c), Reactome (d), and GO (e) pathways. f–h GSEA (hypeR) on genes regulated by TWISTNB, with enrichment analysis for KEGG (f), Reactome (g) and GO (h) pathways. Red color indicates protumoral signal pathways and critical biological functions.

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