Fig. 3: Discriminative cfRNAs in plasma. | npj Precision Oncology

Fig. 3: Discriminative cfRNAs in plasma.

From: Diagnostic and prognostic potential of cell-free RNAs in cerebrospinal fluid and plasma for brain tumors

Fig. 3

a, b Volcano plots showing DE plasma cfRNAs from (a) glioma patients or (b) meningiomas patients versus tumor-free controls. Red dots indicate DE cfRNAs at BH-FDR <0.1 (Wald test, two-sided p-values) and absolute log2 fold change >0.5. Blue dots represent DE cfRNAs with mean normalized counts <5. Gray dots represent non-significant cfRNAs. c Bar plots showing frequency of LASSO (left) and Boruta (right) feature selection out of 100 iterations for candidate cfRNAs that passed the inclusion criteria. cfRNA features selected for three sets of one-versus-other class comparisons are shown. Different colors represent different types of RNAs. d Heatmap of plasma cfRNA features (row) among each group of samples (column). Ward D2 clustering at Euclidean distance was performed for row and column. Z score normalization was performed on the normalized reads.

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