Fig. 1: Overview of the results of the high-throughput drug screen. | npj Precision Oncology

Fig. 1: Overview of the results of the high-throughput drug screen.

From: Functional screening identifies kinesin spindle protein inhibitor filanesib as a potential treatment option for hepatoblastoma

Fig. 1

Efficacy of tested drugs in six HB models grown as spheroids was evaluated using DSS. DSS ≥ 10 was considered effective (dotted red line) (A). The number of compounds with DSS ≥ 10 (B). Taking into account the effect of the drug on healthy primary hepatocytes, sDSS was calculated. Drugs with sDSS ≥ 10 were considered effective and non-toxic (C). The top 10 compounds with the highest sDSS of each cell line are shown (D) intensity of color depicts DSS. Venn diagram shows overlapping compounds with sDSS ≥ 10 (E). The dose–response curves of these eight overlapping compounds are shown in panel F. DSS drug sensitivity score, sDSS selective drug sensitivity score, PH primary hepatocytes.

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