Fig. 4: Cell Painting reveals filanesib-treated cells to show signs of mitotic catastrophe. | npj Precision Oncology

Fig. 4: Cell Painting reveals filanesib-treated cells to show signs of mitotic catastrophe.

From: Functional screening identifies kinesin spindle protein inhibitor filanesib as a potential treatment option for hepatoblastoma

Fig. 4

Representative images of HB-279 cells treated with either 10 nM filanesib, 10 nM luminespib, or control (DMSO) (A–E). Four different wave lengths were used to capture the morphological features. Different stains were used to visualize the nuclei (A) endoplasmic reticulum (B) cellular membranes and microfilaments (C) and mitochondria (D). Merged images are presented in (E). The nuclei of filanesib-treated cells displayed a fragmented morphology (A). Scale bar = 50 µm, scale bar in close-up images = 10 µm.

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