Fig. 9: RNA-sequencing profile of HB-279 differs from other HB models. | npj Precision Oncology

Fig. 9: RNA-sequencing profile of HB-279 differs from other HB models.

From: Functional screening identifies kinesin spindle protein inhibitor filanesib as a potential treatment option for hepatoblastoma

Fig. 9

KIF11 RNA expression in six PDX cell models relative to primary hepatocytes is shown in panel A Unsupervised principal component analysis of the expression of the most variably expressed genes (B) and of a subset of mitotic spindle-related genes (C) shows the relation of untreated HB-279 cells to the other HB models. Each dot represents a single replica sample. Gene set enrichment analysis comparing the RNA-sequencing results of HB-279 to the other models using Hallmark gene sets was done. D shows the top 10 highest and lowest scoring Hallmark gene sets with FDR < 0.25. PH primary hepatocytes, PC principal component, NES normalized enrichment score.

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