Fig. 9: The mechanism map of ARHGAP4 promoting CRC stemness and progression.
From: ARHGAP4/MYH9/β-catenin/c-Jun positive feedback loop promotes colorectal cancer stemness
ARHGAP4 is highly expressed in CRC. This makes ARHGAP4 and MYH9 interact more frequently and promotes the phase separation ability of MYH9. The increased phase separation ability further recruits GSK3β and increases the assembly of GSK3β ubiquitinated complexes. Subsequently, GSK3β was degraded by ubiquitination and the activation of the β-catenin pathway promoted the malignant biological behavior of CRC. At the same time, the downstream target gene c-Jun of the pathway is up-regulated and in turn transcriptionally regulates MYH9 and ARHGAP4 to form a positive feedback loop.
