Fig. 4: Integration of Deepath-MSI into the clinical workflow for efficient MSI screening. | npj Precision Oncology

Fig. 4: Integration of Deepath-MSI into the clinical workflow for efficient MSI screening.

From: Deepath-MSI: a clinic-ready deep learning model for microsatellite instability detection in colorectal cancer using whole-slide imaging

Fig. 4

The diagram compares the current workflow, where all colorectal cancer cases (N = 2236) undergo IHC/PCR testing, with the proposed Deepath-MSI workflow. The proposed approach utilizes Deepath-MSI analysis of H&E slides for initial screening, directing only predicted MSI-H cases (N = 322, 14.4%) to confirmatory IHC/PCR. This potentially excludes approximately 90.7% of MSS patients from further testing, significantly reducing the burden of ancillary tests.

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