Fig. 5: PTGDS is negatively correlated with immune infiltration and cytokine interactions.
From: Pan cancer research reveals the role of PTGDS in tumor suppression and immune regulation
a Bar charts showing the correlation between PTGDS and ESTIMATEScore, ImmuneScore, and StromalScore (left), and scatter plots of the top 6 correlations for each Score (right). b Correlation between PTGDS expression and immune checkpoints in pan-cancer. c Correlation between PTGDS and immune subtypes. d Expression of PTGDS in 6 immune subtypes across six types of cancer. e Heatmaps showing the correlation between PTGDS expression and chemokines (top left), receptors (bottom left), and immune stimulants (top right), and a heatmap of PTGDS promoter methylation levels with immune stimulants (bottom right). f Box plots of PTGDS expression before and after cytokine therapy. ESTIMATEScore is a score that estimates the presence of stromal and immune cells in malignant tumor tissues using expression data. (Z-score test: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.).
