Fig. 2: Violin plots of CoDA features across clinical subgroups. | npj Precision Oncology

Fig. 2: Violin plots of CoDA features across clinical subgroups.

From: Collagen disorder architecture features are associated with clinical, molecular, genetic factors and survival outcomes in colon cancer

Fig. 2

Violin plots depict differences in collagen architectural features—CF Fragmentation, CF Bundling, CF Anisotropy, CF Density, and CF Rigidity—across clinical subgroups: (A) Overall Stage (I–II vs. III–IV), (B) T Stage (T1–2 vs. T3–4), (C) N Stage (N0 vs. N + ), and (D) M Stage (M0 vs. M1). Statistical significance was assessed with Bonferroni-adjusted p-values (*p). Significant differences were observed in CF Fragmentation, CF Anisotropy, and CF Rigidity for Overall Stage; CF Anisotropy, CF Density, and CF Rigidity for T Stage; all CoDA features for N Stage; and CF Fragmentation and CF Bundling for M Stage. These findings demonstrate a consistent association between collagen architectural features and clinical staging, highlighting the potential of CoDA features as non-invasive biomarkers of tumor progression and metastatic potential.

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