Fig. 9: CoDA-Based Risk Stratification of Overall Survival Across Mutational Subtypes.

Kaplan–Meier (KM) curves illustrating overall survival (OS) stratified by CoDA-derived risk groups (high vs. low risk) within mutational subtypes: (A) KRAS wild type, (B) KRAS mutated, (C) BRAF wild type, and (D) BRAF mutated. Significant OS differences were observed in all mutational subgroups except BRAF-mutated cases (p = 0.60), indicating a potential reduced prognostic impact of CoDA features in this mutation subset.