Fig. 1: Clinical course and treatment timeline for Patient No. 1.

CNS central nervous system, ICT Department of Investigational Cancer Therapeutics, mo months, NED no evidence of disease, PD progressive disease, pMMR mismatch repair proteins proficiency, SRS stereotactic radiosurgery. Carcinoembryonic antigen (CEA) reference range ≤3.8 ng/mL.