Table 3 Overview of the 19 publications with the goal of predicting current or future neuromotor outcomes for infants

From: A systematic review of portable technologies for the early assessment of motor development in infants

 

Author

Year

Setting

Sample size

Data collection age

Outcome OR ground truth

Technology

Goal

Best Prediction Result

Cerebral palsy

1

Adde76

2010

Clinic

30

10–15 weeks CA

CP at 4–7 years;

GMA at 10–15 weeks CA

Video

Predict - Future

CP Prediction: AUC-ROC = 0.88, Sn = 0.85, Sp = 0.88

2

Stahl77

2012

Clinic

82

10–18 weeks CA

CP at 2–5 years

Video

Predict - Future

CP Prediction: Sn = 0.85, Sp = 0.96, Acc = 0.94

2

Adde45

2013

Clinic

52

9–17 weeks CA

CP at 2 years;

GMA at 9–14 weeks CA

Video

Automate, Predict - Future

CP Prediction: AUC-ROC = 0.85, Sn = 0.89, Sp = 0.74

3

Rahmati78

2014

Lab

78

10–18 weeks CA

CP at 5 years

Video

Predict - Future

CP Prediction: Sn = 0.50, Sp = 0.95, Acc = 0.87

4

Rahmati42

2016

Lab

78

10–18 weeks CA

Unclear diagnosis of CP

Sensor; Video

Predict - Future

Using video: CP Prediction: Sn = 0.86, Sp = 0.92, Acc = 0.91, AUC-ROC = 0.93

5

Orlandi47

2018

Clinic

173

3–5 months CA

Bayley III at 18–24 months for motor impairment or CP diagnosis;

GMA at 3–5 months CA

Video

Automate, Predict - Future

CP Prediction: Acc = 0.92, Sn = 0.44, Sp = 0.99, AUC = 0.82

6

Raghuram79

2019

Clinic

152

3.81 ± 0.4 months CA

Bayley-III at 18–24 months for CP diagnosis

Video

Predict - Future

CP Prediction: Acc = 0.66, Sn = 0.79, Sp = 0.63, PPV = 0.37, NPV = 0.91

7

Ihlen80

2019

Clinic

377

12 weeks CA

CP at 18 months - 5 years

Video

Predict - Future

CP Prediction: Sn = 0.93, Sp = 0.82, PPV = 0.38, NPV = 0.99, AUC-ROC = 0.87

8

Moro81

2022

Lab

142

40 weeks PMA

Bayley-III at 30 months

Video

Predict - Future

CP Prediction: Acc = 0.86

9

Raghuram82

2022

Clinic

252

3–5 months CA

CP diagnosis at 18–24 months

Video

Predict - Future

CP Prediction: Sn = 0.55, Sp = 0.80, PPV = 0.26, NPV = 0.93

10

Groos83

2022

Clinic

557

11–13 weeks

CP diagnosis at 18 months - 5 years

Video

Predict - Future

CP Prediction: Sn = 0.71, Sp = 0.94, PPV = 0.68, NPV = 0.95, Acc = 0.91

ASD tendency

11

Doi93

2022

Lab

41

4 months

M-CHAT for risk of ASD at 18 months

Video

Predict - Future

ASD Tendency Prediction: Sn = 0.71, Sp = 0.97, F1 = 0.77, AUC-ROC = 0.90, ROC-PR = 0.69

12

Doi84

2023

Clinic

73

2.13 ± 0.66 days CA

M-CHAT at 18 months CA

Video

Predict - Future

ASD Tendency Prediction: Sn = 0.57; Sp = 0.97

Other neurodevelopmental delay/disorders

13

Chambers85

2020

Home; Clinic

104

3–8 months CA

Bayley Infant Neurodevelopmental Screener

Video

Predict - Current

N/A

14

Tacchino70

2020

Home; Clinic

67

39–41 weeks PMA;

8–12 weeks after birth

MRI or GMA at 8–12 weeks after birth

Video

Illuminate, Predict - Current

Preterm Status Classification: Acc = 0.95

15

Fitter43

2020

Home

36

1–20 months CA

Parent report at 24 month

Sensor

Predict - Current, Predict - Future

DD Risk Level Classification: Acc = 0.89, Pr = 0.95, Rc = 0.88, F1 = 0.91;

DD Outcome Prediction: Acc = 0.90, Pr = 0.82, Rc = 1, F1 = 0.90

16

Garello86

2021

Lab

55

40 weeks PMA

Bayley-III at 2 years

Video

Predict - Future

Neuromotor Disorders Prediction: Acc = 0.78, Sn = 0.79 Sp = 0.78

17

Celik34

2023

Clinic

101

TD: 14.1 ± 2.9 weeks CA; AR: 12.6 ± 3.2 weeks CA

GMA at 9–20 weeks CA

Sensor

Illuminate, Predict - Current

GMA score: Sn = 0.85; Sp = 0.83; Acc = 0.83

18

de’Cavalieri44

2023

Home

17

6.35 ± 2.95 months CA

AIMS/IMP at 6.35 ± 2.95 months CA

Sensor

Predict – Future, Predict - Current

N/A

19

Taleb87

2023

Home; Clinic

21

TD: 15.8 ± 14 weeks CA; Bronchiolitis: 13 ± 12.5 weeks CA; SMA: 80.8 ± 45.5 weeks CA

TD: 15.8 ± 14 weeks CA; Bronchiolitis: 13 ± 12.5 weeks CA; SMA: 80.8 ± 45.5 weeks CA

Video

Predict-Current

Neuromotor Disorders Prediction: Pr = 0.81; Rc = 0.86; Acc = 0.86; AUC-ROC = 0.72

  1. CA Corrected age, PMA Post-menstrual age, GMA General Movement Assessment, CP Cerebral palsy, HINE Hammersmith Infant Neurological Exam, ASD Autism Spectrum Disorder, M-CHAT Modified Checklist for Autism in Toddlerhood, TINE Touwen Infant Neurological Examination, Bayley-III Bayley Scales of Infant and Toddler Development, 3rd Edition, AIMS Albert Infant Motor Scale, PDMS-2 Peabody Developmental Motor Scales 2nd Edition, IMP Infant Motor Profile, SMA Spinal Muscular Atrophy, Sn Sensitivity, Sp Specificity, Acc Accuracy, AUC-ROC Area under the receiver operating characteristic curve, PR Precision recall, NPV Negative predictive value, PPV Positive predictive value, Rc Recall.