Table 2 Untargeted lipidomic analysis of plasma EVs and lymph EVs

From: Platelet extracellular vesicles preserve lymphatic endothelial cell integrity and enhance lymphatic vessel function

DOWN

UP

Identification

FC

p-value (corr)

Identification

FC

p-value (corr)

LPC(14:0)

0.34

0.0017

PC(36:4)

1.45

0.022

LPC(16:0)

0.47

0.0027

 

LPC(14:0)

0.49

0.003

LPC(18:0)

0.53

0.011

LPC(18:2)

0.62

0.018

PC(16:0_22:6)

0.68

0.047

FFA C16:1n7

0.79

0.018

  1. Lipids contained in EVs were analyzed by LC-QTOF-MS and were either down- or upregulated in lymph EVs compared to plasma EVs. The underscore symbol “_” beside the acyl side chain for TGs or PCs refers to acyl chains for which the sn position remains to be ascertained. When MSMS failed to identify each acyl chain, the sum of carbon chains and doubles bound is indicated. n = 3 (each n is a pool of 2–4 mice). FC fold change, FFA free fatty acid, LPC lysoglycerophosphatidylcholine, PC diacylglycerophosphatidylcholine.
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