Fig. 1: Schematics of DRCTdb. | Communications Biology

Fig. 1: Schematics of DRCTdb.

From: DRCTdb: disease-related cell type analysis to decode cell type effect and underlying regulatory mechanisms

Fig. 1

DRCTdb integrates single-cell multi-omics data, including scRNA-seq and scATAC-seq, to identify disease-related cell types (DRCTs). The workflow leverages GWAS datasets to map risk SNPs to cell-type-specific chromatin landscapes. Regulatory mechanisms such as transcription factor activity, cell-cell communication, and gene regulatory networks are analyzed to understand how these DRCTs contribute to disease.

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