Fig. 4: The excitatory signal input of MD to fast spiking (FS) neurons in ACC L3 did not change after nerve injury. | Communications Biology

Fig. 4: The excitatory signal input of MD to fast spiking (FS) neurons in ACC L3 did not change after nerve injury.

From: Deconstruction the feedforward inhibition changes in the layer III of anterior cingulate cortex after peripheral nerve injury

Fig. 4

A Schematic diagram of experimental design. B Upper: The whole-cell patch recording of FS neurons in ACC L3. Lower: Representative traces of EPSC in Sham and CPN groups. C Histogram of EPSC amplitude values in Sham and CPN group (Two-tailed unpaired t-test, t = 0.28, df = 13, P = 0.78; n = 7 neurons/3 Sham mice, n = 8 neurons/3 CPN mice). D Histogram of EPSC Tau in Sham and CPN group (Two-tailed unpaired t-test, t = 1.087, df = 13, P = 0.30; n = 7 neurons/3 Sham mice, n = 8 neurons/3 CPN mice). E Examples showing that the recorded FS neurons are PV-positive neurons, scale bar: 20 μm. F Representative traces showed the voltage response of FS neurons to 200 pA current pulse in the Sham and CPN group. G Quantification of AP number fired under current injection (Two-way ANOVA, Interaction, F(7, 112) = 9.57, P < 0.001; Sham vs. CPN, F(1, 16) = 1.49, P = 0.24; n = 9 neurons/3 Sham mice, n = 9 neurons/3 CPN mice).

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