Fig. 5: Nanopore passage model of nucleosomes.
From: Nucleosomal DNA unwinding pathway through canonical and non-canonical histone disassembly
A model of nucleosome passage through nanopores for each current value state. The nucleosome approaches the pore (top left panel), only the DNA located at the end of the nucleosome enters the nanopore (bottom left panel), tethered by the pore before unwinding (second from left), triggers unwinding, a process that dissociates the H2A-H2B dimer (top middle), which proceeds primarily by H2A.B variants In the process of H2A-H2B dimer retraction into the pore, the H2A-H2B dimer further undergoes a pore-stacking state where the H2A-H2B dimer is stuck in the pore, although this process is not favored by the H2A.B variant. Eventually, only the DNA dissociated from the histone passes through the pore (middle right), resulting in complete DNA passage (bottom right).
