Fig. 3: Altered gene expression profile in Sod2-deficient oocytes. | Communications Biology

Fig. 3: Altered gene expression profile in Sod2-deficient oocytes.

From: Maintaining mitochondrial DNA copy number mitigates ROS-induced oocyte decline and female reproductive aging

Fig. 3

a The Venn diagrams illustrating the numbers of transcripts that are up or down-regulated in MII oocytes of 6-month-old L/L, Cre female mice. b Volcano plot showing differentially expressed genes (DEGs; downregulated, green; upregulated, red) in L/L, Cre oocytes compared with L/L from 6-month-old mice oocytes, with significant DEGs highlighted. c Heatmap illustrating the manual-sorted pathways derived from DEGs. d Gene Ontology (GO) enrichment analysis of downregulated DEGs in L/L, Cre oocytes relative to L/L oocytes from 6-month-old mice. e Gene Ontology (GO) enrichment analysis of upregulated DEGs in L/L, Cre oocytes relative to L/L oocytes from 6-month-old mice.

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