Fig. 6: Proliferative consequences of the T-cell-CD14+ cell interaction in metastatic melanoma. | Communications Biology

Fig. 6: Proliferative consequences of the T-cell-CD14+ cell interaction in metastatic melanoma.

From: Computational immune synapse analysis reveals T-cell interactions in distinct tumor microenvironments

Fig. 6

a Proliferative (Ki67+, orange boxes) T-cell synapses are significantly stronger than non-proliferative (Ki67-, green boxes) T-cell synapses, for both loaded CD14+ cells and melanoma cells (p = 4.2 × 10–4 and p = 0.021 respectively). Proliferative T-cell synapses with loaded CD14+ cells are stronger than those with unloaded CD14+ cells (#p = 6.0 × 10–5) and the null model (@, p = 9.5 × 10–7). In the stroma, there are no significant differences in synapses between proliferative and non-proliferative T-cells with either loaded or unloaded CD14+ cells. b Paired difference plot comparing the fraction of intratumor Ki67+ T-cells vs. synapse strength. The fraction of T-cells that are Ki67+ is significantly greater for T-cells with positive synapses compared to non-positive synapses, both for synapses to loaded CD14+ cells (p = 2.8 × 10–4) and to melanoma cells (p = 0.014). Black lines indicate a positive difference while red lines indicate a negative difference.\(\bar{{\rm{\sigma }}}\): sample-level mean synapse strength.

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