Fig. 4: Transcriptomic profiles of THP-1 cells from HSEs after exposure to UVA at 80 J/cm2.
From: Characterization of macrophages associated with human skin models exposed to UV radiation
A PCA plot based on the normalized count data from each sample. B Heatmap of the DEGs is shown with |log2 FC| >1 and adjusted p value < 0.05. C Volcano plot showing all mapped genes of the sorted THP-1 cell line. Red dots indicate DEGs with up- or downregulated genes (|log2 FC|> 1, adjusted p value < 0.05). D Dot plots of the significantly enriched GO terms are shown according to the gene ratio. The size of the dots represents the number of DEGs, and the color represents the value of the adjusted p value (p.adjust). BP biological process, CC cellular component, MF molecular function. E Bar plot of the KEGG terms ordered according to the value of p.adjust. The red and blue bars indicate the number of transcripts upregulated and downregulated in the HSE.THP1.UV group. F Enrichment plots of upregulated and downregulated genes identified by GSEA based on the hallmark database. Nominal p value < 0.001. The leading-edge genes correlated with the response to UVA exposure and contributed to the enrichment scores (ESs).
