Fig. 6: PIANO-predicted ΔΔGs exhibit the interpretation of de novo missense mutations from neurodevelopmental disorders. | Communications Biology

Fig. 6: PIANO-predicted ΔΔGs exhibit the interpretation of de novo missense mutations from neurodevelopmental disorders.

From: Graph masked self-distillation learning for prediction of mutation impact on protein–protein interactions

Fig. 6

a The distributions of PIANO-predicted ΔΔGs for de novo missense mutations from neurodevelopmental disorder probands (case, n = 643) and from unaffected siblings of autism spectrum disorder probands (control, n = 129). The center lines in boxplot graphs indicate median, the bounds of boxes indicate 25th and 75th percentiles. b Case variant enrichment for different methods at the 80th percentile. Error bars indicate 95% confidence intervals of ORs.

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