Fig. 3: Slc25a1 deletion alters metabolic gene expression in mice. | Communications Biology

Fig. 3: Slc25a1 deletion alters metabolic gene expression in mice.

From: The mitochondrial citrate carrier SLC25A1 regulates metabolic reprogramming and morphogenesis in the developing heart

Fig. 3

A Volcano plots of Nanostring metabolic transcript profiling comparing gene expression of Slc25a1-/- and Slc25a1+/+, Slc25a1+/- and Slc25a1+/+, and Slc25a1-/- and Slc25a1+/- E17.5 hearts. Blue denotes downregulated transcripts. Yellow denotes upregulated transcripts. See Supplemental Data 3. B Heat map depicting transcripts differentially expressed across genotypes in A. Transcripts in rows were selected by ANOVA multiple comparisons followed by Benjamini-Hochberg correction (q < 0.05) and clustered using Kendall-Tau (see Supplemental Data 3). Each column represents an individual animal. C Gene ontologies identified with Metascape from genes differentially expressed in Slc25a1-/- and Slc25a1+/- versus Slc25a1+/+ hearts. D Geneset enrichment analysis of oxidative phosphorylation, glycolysis, hypoxia, and fatty acid metabolism genes in Slc25a1+/+ vs. Slc25a1-/- and Slc25a1+/+ vs. Slc25a1+/- E17.5 hearts. E Heatmaps visualizing gene expression of oxidative phosphorylation and glycolysis genes from Nanostring transcript profiling in E17.5 Slc25a1+/+ vs. Slc25a1-/- hearts. Blue denotes reduced expression; red denotes increased expression.

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