Fig. 6: In silico modeling reveals glucose dependency and impaired oxidative phosphorylation with SLC25A1 loss. | Communications Biology

Fig. 6: In silico modeling reveals glucose dependency and impaired oxidative phosphorylation with SLC25A1 loss.

From: The mitochondrial citrate carrier SLC25A1 regulates metabolic reprogramming and morphogenesis in the developing heart

Fig. 6

A PCA of the CardioNet simulation revealed a clear clustering of Slc25a1+/+, Slc25a1+/-, and Slc25a1-/- hearts by Slc25a1 genotype. B Unsupervised hierarchical clustering of significantly altered flux distributions. Two-way ANOVA with post hoc Tukey’s test followed by multiple comparison analysis (FDR < 1% after Benjamini, Krieger and Yekuteli). C Predicted flux rates for glucose uptake, and D oxidative phosphorylation in response to SLC25A1 deletion. Box plot parameters are defined by the minimum value, the first quartile, the median, the third quartile, and the maximum value. *P < 0.05; ****P < 0.00005.

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