Fig. 1: GPR39 expression.
From: Targeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension
a, b Quantitative analysis of GPR39 mRNA (n = 5) and protein (n = 3) expression levels in the aorta of hypertensive patients (HTN) compared to normotensive patients. c, d Quantitative analysis of GPR39 mRNA and protein expression levels in the aorta of Ang II-infused mice compared to control mice (n = 6). e, f An immunofluorescence image depicting aortic cells marked with GPR39 (red) and DAPI (blue) at 40× magnification. Scale bar represents 50 μm. White arrows highlight endothelial cells with elevated GPR39 expression. Quantitative analysis of GPR39 expression is presented. g, h Analysis of GPR39 mRNA and protein expression levels in HUVECs post 48-h Ang II induction versus the PBS control group (n = 6). Data are expressed as mean ± SEM. Statistical significance is denoted as follows: ns (not significant), *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
