Fig. 3: GPR39 knockout attenuates Ang II-induced vascular fibrosis.
From: Targeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension
a Quantification of fibrosis in mouse aortic vessels (n = 6) using Masson staining. The fibrotic area was meticulously calculated. b, c Analysis of fibrosis markers in aortic vessels at the protein (α-SMA, TGF-β and COL-1, n = 6) and mRNA levels (α-SMA, TGF-β and COL-1, n = 6). GAPDH served as the loading control. Data are presented as mean ± SEM, with statistical significance indicated as NS (not significant), *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
