Fig. 1: LINC02139 is upregulated in GC and the high LINC02139 level is associated with poor clinicopathologic features. | Communications Biology

Fig. 1: LINC02139 is upregulated in GC and the high LINC02139 level is associated with poor clinicopathologic features.

From: LINC02139 interacts with and stabilizes XIAP to regulate cell proliferation and apoptosis in gastric cancer

Fig. 1

A Differentially expressed lncRNAs are displayed as heatmaps. Red represents upregulated lncRNAs and blue represents downregulated lncRNAs. Venn diagrams show the overlaps of GSE53137 and GSE95667. B LINC02139 expression levels in GSE53137 and GSE95667 are shown as scatter plots. ***P < 0.01, ****P < 0.001. C LINC02139 expression levels in GC and normal tissues measured by qRT-PCR are displayed as waterfall plots and scatter plots. ****P < 0.001. D qRT-PCR was conducted to test LINC02139 expression in GC cell lines and immortalized gastric mucosal cell line GES-1. One-way ANOVA and Dunnett’s T3 multiple comparison tests. **P < 0.05. E In situ hybridization (ISH) analysis was adopted to ascertain the LINC02139 expression in normal gastric mucosa and GC tissues. F LINC02139 expression in the cytoplasmic and nuclear fractions in GES-1 and AGS cells was determined by qRT-PCR. GAPDH represents cytoplasmic control and nuclear-enriched abundant transcript 1 (NEAT1) represents nuclear control. G The coding potential of LINC02139 was explored through the Coding Potential Assessment Tool (CPAT) and Coding Potential Calculator (CPC). HOX transcript antisense RNA (HOTAIR) and GAPDH were set as non-coding and coding RNA control, respectively. Scale bars, 100 μm in (E).

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