Fig. 2: Gene mutation difference between CYAs and OAs in different hematologic tumors.
From: Genomic differences of patients with hematologic malignancies in different age groups
a Tumor mutational burden (TMB) (i.e., the number of coding mutations per megabase) of CYAs and OAs in various hematologic tumor types/subtypes. Tumor types/subtypes are ordered by the median TMB of corresponding tumor cases. Tumor types/subtypes show (non-)significant differences between CYAs and OAs (****FDR < 0.0001; *FDR < 0.05; ns FDR > 0.05). b Genes with significant differences in mutation rates comparing CYAs and OAs in hematologic tumor types. The bar length in the left panel represents the absolute value of the difference between CYA and OA mutation rates. Pink indicates higher mutation rates in CYAs, and blue indicates higher mutation rates in OAs. Bar lengths in the right panel represent the negative logarithm of FDR of mutation rate difference between CYAs and OAs (FDR < 0.05). Greater bar lengths indicate more significant differences. c Genes with significant differences in mutation rates between CYAs and OAs in hematologic tumor subtypes. Circle size represents the absolute value of the difference between CYA and OA mutation rates. Pink indicates higher mutation rates in CYAs, and blue indicates higher mutation rates in OAs. The transparency of the circle indicates the negative logarithm of FDR of mutation rate difference between CYAs and OAs (FDR < 0.05). Darker colors indicate more significant differences.
