Fig. 3: Simulation results of the extended hABM. | Communications Biology

Fig. 3: Simulation results of the extended hABM.

From: Spatiotemporal modeling quantifies cellular contributions to uptake of Aspergillus fumigatus in the human lung

Fig. 3

A The hABM simulations results without AMs. The light blue line shows the relative uptake by type 2 AECs matching the analytical solution from the extended Malthus ODE Model (dark red dotted). The green curves show the relative uptake by type 1 AECs, and the orange lines show the overall uptake by AECs. Different line styles denote different values of \({r}_{{up}0}^{{AEC}1}\). B The spatial distribution of conidia being confronted with type 1 or type 2 AECs averaged over all hABM simulations. CF The blue lines denote the uptake by AMs, and the green lines denote the uptake by type 1 and type 2 AECs combined. The orange lines denote the overall uptake. The corresponding parameter combination is written at the top. In (C), different line styles denote different values of \({r}_{{up}0}^{{AM}}\). In (D) different line styles denote varied delayed chemokine secretion \({t}_{{s}_{{AEC}}}\) scenarios. In (E) different line styles denote different AM numbers \({n}_{{AM}}\). In (F) different line styles denote different values of \({r}_{{up}0}^{{AEC}1}\). In (A, CF) error bars represent the 95% confidence interval as obtained from the standard error of independent Bernoulli trials.

Back to article page