Fig. 3: Alignment and origin of resistance and virulence plasmids. | Communications Biology

Fig. 3: Alignment and origin of resistance and virulence plasmids.

From: Two outbreak cases involving ST65-KL2 and ST11-KL64 hypervirulent carbapenem-resistant Klebsiella pneumoniae: similarity and diversity analysis

Fig. 3

A Linear alignment of blaKPC-2-bearing structure on pK56649-2-KPC (plasmid of ST11-KL64 hv-CRKP) and two classical surroundings, Tn1724-based structure and Tn4401. ORFs are indicated by arrows. Sequences of shared homology are marked by grey shading. B Linear alignment of blaNDM-13-bearing pK56649-4-NDM of K56649 (the ST11-KL64 hv-CRKP) and pNDM13-SR33 of Salmonella enterica SR33. C Circular alignment analysis of plasmid pK56649-3-VIR (plasmid of ST11-KL64 hv-CRKP), pK22877-1-VIR (plasmid of ST65-KL2 CR-hvKP) and two classical hypervirulent plasmids, pLVPK and pK2044. Virulence genes were marked by red shading. D Maximum-likelihood phylogenetic tree of pK56649-2-KPC and its homological plasmids. E Maximum-likelihood phylogenetic tree of pK56649-4-NDM and its homological plasmids. Circles from the inside out showed species, carbapenemase, country and year, and the number in the circle was tree scale.

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