Fig. 7: Gene–chemical interplay.
From: Data-driven discovery of the interplay between genetic and environmental factors in bacterial growth
A Evaluating the changes in K triggered by gene–chemical combinations. ΔGEijExpected is the sum of Base, ΔGi, and ΔEj; all other labels are described in Fig. 6A. Red, blue, and gray represent Offset, Strengthen, and Additive mechanisms in gene–chemical crosstalk. Three examples of Additive in NN, Strengthen in PN, and Offset in PP are illustrated. B An example diagram of the relative frequency of the three mechanisms. PP, PN, and NN combinations shown in Fig. 6D are presented. C Relative frequencies of Offset in NN, PN, and PP at each Base. The broken lines indicate 50%. D Distributions of the Offset and Strengthen relative frequencies in NN, PN, and PP. The statistical significance of the Mann–Whitney U test is shown. E Comparing the Offset to the additive changes. The magnitudes of the Offset and the additive changes are illustrated as the black arrow lines of GEij - GEijExpected and ΔGi + ΔEj. F An example of the correlation between the magnitude of Offset and the additive changes. Correlation coefficients and the p-value are indicated. G Correlation between the magnitude of Offset and the additive changes in all combinations in PP and NN. Color gradations indicate the correlation coefficients in the linear scale and the corresponding p-values in the logarithmic scale.
