Fig. 1: The characteristics of circRNAs and the roles of CPIs in different cancers. | Communications Biology

Fig. 1: The characteristics of circRNAs and the roles of CPIs in different cancers.

From: Mechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancer

Fig. 1

a Schematic illustration of circRNA biogenesis. Exons from pre-RNA undergo back-splicing to form four types of circular RNAs, which are then transported to the cytoplasm via the nuclear pore complex. In the cytoplasm, they perform various biological functions such as acting as miRNA sponges, scaffolding RBPs, and facilitating protein translation. Finally, they are packaged into extracellular vesicles(EVs) and released into the extracellular space. b–i Individual roles of CPIs in different cancers. The upward blue arrows indicate that CPIs promote tumor progression, while the downward arrows represent their inhibition of tumor progression.

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