Fig. 2: CPI-mediated regulation of gene expression in cancers. | Communications Biology

Fig. 2: CPI-mediated regulation of gene expression in cancers.

From: Mechanisms and therapeutic implications of gene expression regulation by circRNA-protein interactions in cancer

Fig. 2

a CPIs modulating transcription. circ-DONSON recruits the NURF complex to facilitate GC progression. circRNF10 interacts with DHX15 to suppress BC’s proliferation and migration. b CPIs affecting alternative splicing. circURI1 inreracts with hnRNPM to suppress GC metastasis. circRAPGEF5 interacts with RBFOX2 to facilitate EC cells’ proliferation. c CPIs affecting translation. circPTPRA binds to IGF2BP1 to suppress tumor progression. Hsa_circ_0005358 sequesters PTBP1 to suppress cancer metastasis. d CPIs affecting RBP’s subcellular localization. circDCUN1D4 facilitates HuR’s translocation to suppress tumor metastasis. The upward blue arrows following each tumor abbreviation indicate that CPIs promote tumor progression, while the downward arrows represent their inhibition of tumor progression.

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