Table 2 The list of CPIs mediating tumor drug resistance in different cancer types
Tumor type | Corresponding drugs | circRNA | RBP | Mechanisms* | Drug resistance | References |
|---|---|---|---|---|---|---|
Breast cancer | trastuzumab | circCDYL2 | GRB7 | b | Upregulated | |
trastuzumab | circ-BGN | OTUB,SLC7A11 | e | Upregulated | ||
tamoxifen | circPVT1 | MAVS | b | Upregulated | ||
tamoxifen | circRNA-SFMBT2 | ERα, RNF181 | b | Upregulated | ||
paclitaxel(PAX) | circAMOTL1 | AKT | b | Upregulated | ||
NSCLC | cisplatin(DDP) | circ_0000079 | FXR1 | b | Downregulated | |
gefitinib | circSETD3 | FXR1 | d | Upregulated | ||
Bladder cancer | cisplatin | circLIFR | MSH2 | d | Downregulated | |
cisplatin | circARHGAP10 | MATIIa,TRIM25 | e | Downregulated | ||
cisplatin | circ0008399 | WTAP | d | Upregulated | ||
Ovarian cancer | cisplatin | circITGB6 | IGF2BP2 | f | Upregulated | |
cisplatin | circPBX3 | IGF2BP2 | a | Upregulated | ||
CSCC | cisplatin | circARHGAP5 | AUF1 | d | Downregulated | |
NPC | cisplatin | circIPO7 | YBX1 | c | Upregulated | |
CML | imatinib | circ_SIRT1 | EIF4A3 | d | Upregulated | |
ccRCC | sunitinib | circME1 | U1 snRNP | e | Upregulated | |
Prostate cancer | docetaxel | circARHGAP29 | IGF2BP2 | e | Upregulated | |
HCC | sorafenib | circRNA-SORE | YBX1 | b | Upregulated |
