Fig. 1: Chondrocyte senescence and elevated HNRNPD levels closely associates with the progression of OA. | Communications Biology

Fig. 1: Chondrocyte senescence and elevated HNRNPD levels closely associates with the progression of OA.

From: RNA-binding protein HNRNPD promotes chondrocyte senescence and osteoarthritis progression through upregulating FOXM1

Fig. 1

A The MRI, general and arthroscopic observation of OA cartilage tissues and corresponding non-lesion samples. Black arrowheads indicate the site of cartilage damage. B The HE, Safranin O/fast green, Alcian blue staining (scale bars; up: 600 µm, down: 240 µm), and immunohistochemical staining of HNRNPD and P21 of the cartilage tissues of OA patient and OA model rat (scale bar: 120 µm). C Immunofluorescence analysis of P16INK4AINK4a in the synovium, cartilage surface, and subchondral bone from sham and OA model rats (scale bar: 60 µm). The ratios of immunoreactive cells of P16INK4A (D), HNRNPD (E), and P21 (F) were analyzed. Data were expressed as mean ± SD (n = 5). ***P < 0.001 vs. sham or control group.

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