Fig. 4: HNRNPD promotes chondrocyte senescence and catabolism in vivo in OA. | Communications Biology

Fig. 4: HNRNPD promotes chondrocyte senescence and catabolism in vivo in OA.

From: RNA-binding protein HNRNPD promotes chondrocyte senescence and osteoarthritis progression through upregulating FOXM1

Fig. 4

A, B Immunofluorescence with antibodies to MMP-13, Col II, P53, and P16INK4A in articular cartilage from the DMM-induced OA rats with rAAV-HNRNPD treatment at 10 weeks post-surgery (scale bar: 80 µm). C, D The ratios of immunoreactive cells were quantified in articular cartilage according to immunofluorescence. Data were expressed as mean ± SD (n = 5). *P < 0.05, **P < 0.01 and ***P < 0.001 vs. the sham-operated group; #P < 0.05 and ##P < 0.01 vs. the DMM induction group.

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