Fig. 5: The observed changes in hormone levels during pregnancy and associations between progesterone levels and brain structural metrics.
From: Longitudinal investigation of neurobiological changes across pregnancy
a The observed changes in hormone levels (progesterone, estradiol, testosterone, and cortisol) during pregnancy. Linear mixed-effects models were applied with hormone levels as the dependent variable and gestational week as the predictor, covarying for age. b Associations between progesterone levels and brain structural metrics, including total brain volume, total gray matter volume, total cortical volume, and cortical thickness. The plot is based on Eq. 3. Specifically, brain metrics were the dependent variable and progesterone was the predictor, covarying for age and total intracranial volume. The shaded area represents the 95% confidence interval (95% CI) for the fitted line. Note. **p < .01. ***p < .001.
