Fig. 3: Pleiotropy pattern between CVDs/CeVDs and RFs.
A Number of pleiotropic loci conditioning on different RFs for CVDs and CeVDs. B The fold-enrichment plot illustrates the enrichment of CVDs (CAD, MI, HF, and AF) and CeVDs (AS and AIS) based on their association with cardiometabolic RFs (SBP, TG, LDL-C, HDL-C, T2D, BMI, cIMT). The fold enrichment is represented as the ratio of the −log10(P) cumulative distribution of SNPs conditional on a specific P threshold of 0.001 in one RF to the cumulative distribution for all SNPs of that RF. C Partitioned heritability for CVDs and CeVDs from pleiotropic variants with RFs. The number in each square represents the partitioned heritability as calculated by the number of pleiotropic SNPs of one vascular disease and one RF combination divided by all SNPs of that vascular disease. Different colors represent the heritability after standardizing the heritability of different RFs in each vascular disease. The redder the color, the stronger the association between the risk factor and the disease. CVDs cardiovascular diseases, CeVDs cerebrovascular diseases, RFs risk factors, CAD coronary artery disease, MI myocardial infarction, HF heart failure, AF atrial fibrillation, AIS all ischemic stroke, SBP systolic blood pressure, TG total triglyceride, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, T2D type 2 diabetes, BMI body mass index, cIMT carotid intima-media thickness.
