Fig. 6: Organ, tissue, and cell type enrichment for shared and distinct loci between CVDs and CeVDs.

A–C Organ, tissue, and cell type enrichment for shared loci between CVDs and CeVDs based on all RFs, respectively. The y-axis in all three figures represents the -log (combined P value) which indicates the probability that the set of significantly expressed genes of a given size would have occurred by chance. The smaller the P value, the more likely that the pathway is significantly pathway identified. The x-axis represents different organs, tissues, and cell types in each figure, respectively. D Gene set size distribution and organ enrichment for pleiotropic loci shared by different CVDs or CeVDs and RFs combinations. The upper bar chart represents the number of gene sets shared by CVDs and RFs or CeVDs and RFs, in which different colors mean different CVDs or CeVDs and RFs combinations. In the lower chart, the left rectangles with different colors represent different organ systems, and each square with different colors from red to blue represents the −log (combined P value) of a certain CVDs/CeVDs-RFs combination in one specific organ system enrichment. Each column represents the enrichment of one specific CVDs-RFs or CeVDs-RFs combination, and each row represents the enrichment for different CVDs or CeVDs and RFs pairs in one specific organ system. CVDs cardiovascular diseases, CeVDs cerebrovascular diseases, RFs risk factors, CAD coronary artery disease, MI myocardial infarction, HF heart failure, AF atrial fibrillation, AIS all ischemic stroke, SBP systolic blood pressure, TG total triglyceride, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, T2D type 2 diabetes, BMI body mass index, cIMT carotid intima-media thickness.