Table 1 The number of colocalized loci, 95% credible variants, and genes for pairs of CVDs/CeVDs and RFs

From: Identification of shared genetic etiology of cardiovascular and cerebrovascular diseases through common cardiometabolic risk factors

 

SBP

T2D

BMI

cIMT

TG

LDL-C

HDL-C

Number of colocalized loci

 CAD

99

46

56

18

84

68

103

 MI

68

19

25

16

39

40

45

 AF

29

5

17

1

22

20

25

 HF

5

6

7

0

10

6

14

 AS

13

3

1

0

4

4

3

 AIS

10

0

1

1

7

4

3

Number of 95% credible variants

 CAD

887

334

358

117

581

398

890

 MI

604

240

150

139

262

300

382

 AF

411

116

94

29

209

220

289

 HF

35

104

56

0

124

46

97

 AS

118

54

3

0

40

18

32

 AIS

62

0

3

4

68

25

32

Number of genes

 CAD

139

60

71

22

115

85

142

 MI

101

28

35

25

54

56

62

 AF

41

9

22

1

33

25

36

 HF

6

7

13

0

12

7

18

 AS

16

8

2

0

4

5

3

 AIS

11

0

2

2

8

5

3

  1. The table shows the number of colocalized loci (upper part), the number of 95% credible variants (middle part), and the number of genes (lower part) for each pair of vascular disease and risk factors with posterior probability larger than 80% in colocalization analyses.
  2. CVDs cardiovascular diseases, CeVDs cerebrovascular diseases, RFs risk factors, CAD coronary artery disease, MI myocardial infarction, HF heart failure, AF atrial fibrillation, AS all stroke, AIS all ischemic stroke, SBP systolic blood pressure, T2D type 2 diabetes, BMI body mass index, TG total triglyceride, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, cIMT carotid intima-media thickness.
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