Fig. 6: 1 kHz stimulation-evoked responses were stronger in cortex than CA1, without temporal differences between brain regions. | Communications Biology

Fig. 6: 1 kHz stimulation-evoked responses were stronger in cortex than CA1, without temporal differences between brain regions.

From: Kilohertz electrical stimulation evokes robust cellular responses like conventional frequencies but distinct population dynamics

Fig. 6

a, b Heatmaps showing the normalized fluorescence for all neurons upon 1 kHz stimulation in the (a) CA1 and (b) cortex. The neurons were grouped based on modulation classification (activated (top, red, +), unchanged (middle, gray, Ø), or suppressed (bottom, blue, -)). (c) Average fluorescence trace (± 95% confidence interval) in the CA1 (light green) and cortex (light yellow) for activated neurons during 1 kHz stimulation. d, e 1 kHz stimulation-evoked (d) AUC and (e) time to peak (Wilcoxon rank-sum, statistical results in Suppl. Table 1). f Average fluorescence trace (± 95% confidence interval) in the CA1 (light green) and cortex (light yellow) for suppressed neurons during 1 kHz stimulation. g, h Same as d and e but for suppressed neurons (Wilcoxon rank-sum, statistical results in Suppl. Table 1). Violin plots depict the kernel density overlaid with box plots showing the interquartile range (1x, 1.5x). The white lines in the boxes are the median. All tests are two-tailed. n.s., not significant, *p < 0.05, **p < 0.01, ***p < 0.005.

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