Fig. 5: Short chain fatty acids and metabolites supporting the purine pool.
From: Mice develop obesity and lose myocardial metabolic flexibility months after exertional heat stroke
Fold changes of specific metabolites in all EHS groups compared to their sex-matched EXC on SD. The metabolites chosen have functional significance to myocardial metabolic disorders. a Changes in metabolites identified as short chain fatty acids (SCFAs) or their respective -acyls that are generated in the gut or liver and are an important intermediary energy source. b Changes in metabolites identified as comprising the total “purine pool” in the heart that are a buffer against loss of intra-myocyte [ATP]. Means ± SD or medians ±1 quartile for nonparametric data n = 8 in each group. * = P < 0.05, **<0.01, ***<0.001, ****<0.001. Benjamini Hochberg corrected P (B.H.-Q) values are listed on the far right. Diagrammatic images created with BioRender.com.
