Fig. 6: Vascular and liver function.

a Blood chemistry analyses of total plasma protein and alkaline phosphatase, an intracellular enzyme marker. Dotted areas are predicted values based on Otto et al.⁶⁰ b Luminex® multiplex plasma protein analyses of soluble circulating adhesion molecules. Results in all exertional heat stroke (EHS) and exercise control (EXC) groups compared to a naïve strain-matched controls (blue hatched symbols), c Scoring of histological evidence of liver injury in terms of steatosis and ballooning, along with chemical analysis of plasma alanine aminotransferase (ALP), indicating damaged and/or fatty liver. n = 8 in most groups. In some biochemical analyses insufficient plasma sample was available for testing so the n =(4-8). No data samples were removed for any other reason. * = P < 0.05,** < 0.01, ***< 0.001, ****< 0.001. Statistical tests: Panel (a, c) two sample T or Wilcoxon with B-H Q corrections were below Q < 0.05 for both males and females. Panel b) ANOVA or Kruskal Wallis with post hoc tests were Dunnett T3 for multiple comparisons. Benjamini Hochberg corrected Q values were below 0.1 for all ANOVA P values.