Fig. 3: hsa_circ_0001599 promotes odontogenic differentiation of hDPSCs through the PI3K/AKT signalling pathway. | Communications Biology

Fig. 3: hsa_circ_0001599 promotes odontogenic differentiation of hDPSCs through the PI3K/AKT signalling pathway.

From: hsa_circ_0001599 promotes odontogenic differentiation of human dental pulp stem cells by increasing ITGA2 expression and stability

Fig. 3

a Heatmap showing the genes in LV-NC-treated cells and LV-circ_0001599-treated cells. b Volcano plot of differentially expressed mRNAs in LV-NC- and LV-circ_0001599-treated cells. c The GO enrichment analysis. d The enriched KEGG functional pathways. e Western blot results showed that the expression levels of p-AKT and p-PI3K were increased in the LV-circ_0001599 group. f Treated with PI3K/AKT inhibitor LY294002. g The impact of LY294002 on the odontogenic differentiation of hDPSCs was examined using Western blot. e–g All data were presented as the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns: not significant. e–g n = 3 for each group.

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