Fig. 2: Overexpression of circPLOD2a/b promotes GBM cell invasion and migration under hypoxia. | Communications Biology

Fig. 2: Overexpression of circPLOD2a/b promotes GBM cell invasion and migration under hypoxia.

From: Hypoxia-induced circPLOD2a/b promotes the aggressiveness of glioblastoma by suppressing XIRP1 through binding to HuR

Fig. 2

A, B Results of transwell assays in (A) U87 and (B) LN229 OE-circPLOD2a cells under hypoxia. Scale bar: 100 μm. C, D Quantification of transwell assays in (C) U87 and (D) LN229 OE-circPLOD2a cells, n = 3. E, F Results of CCK8 assays on (E) U87 and (F) LN229 OE-circPLOD2a cells under hypoxia, n = 5. G, H Representative pictures and quantification of wound-healing assays in (G) U87 and (H) LN229 OE-circPLOD2a cells under hypoxia. Scale bar: 250 μm, n = 5. I, J Results of transwell assay in (I) U87 and (J) LN229 OE-circPLOD2b cells under hypoxia. Scale bar: 100 μm. K, L Quantification of transwell assays in (K) U87 and (L) LN229 OE-circPLOD2b cells, n = 3. M, N Results of CCK8 assay on (M) U87 and (N) LN229 OE-circPLOD2b cells, n = 5. O, P Representative pictures and quantification of wound-healing assay (O) U87 and (P) LN229 OE-circPLOD2b cells under hypoxia, n = 5. Scale bar: 250 μm. Data are shown as mean ± SEM (error bars) and analyzed using Student’s t-test (C–P) and ANOVA (E–N).

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