Fig. 6: CircPLOD2a/b promote invasion and migration of GBM cells by suppressing XIRP1 in vivo. | Communications Biology

Fig. 6: CircPLOD2a/b promote invasion and migration of GBM cells by suppressing XIRP1 in vivo.

From: Hypoxia-induced circPLOD2a/b promotes the aggressiveness of glioblastoma by suppressing XIRP1 through binding to HuR

Fig. 6

A, B (A) Representative bioluminescence images and (B) tumor growth curve of tumor-bearing mice intracranially transplanted with corresponding genetically modified U87 cells labeled with luciferase (n = 5–6/ per group). C Relative expression of XIRP1 in CDX tumors, n = 3. D Representative images of IHC staining of Vimentin, E-cadherin and N-cadherin in CDX tumors. Scale bar: 100μm. E, F Relative protein level of Vimentin, E-cadherin, N-cadherin, HuR and XIRP1 in different genetically-modified (E) U87 cells in vitro and in (F) CDX tumors in vivo. Relative integrated density normalized to β-actin was marked above each band. Data are shown as mean ± SEM (error bars) and analyzed ANOVA. Scr: Scramble.

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