Fig. 8: Overlapping expression of DEGs in the injured DRG and cluster SC_R8. | Communications Biology

Fig. 8: Overlapping expression of DEGs in the injured DRG and cluster SC_R8.

From: An atlas of neuropathic pain-associated molecular pathological characteristics in the mouse spinal cord

Fig. 8

a Heatmap of DEGs in the DRG after SNI detected by bulk RNA-seq. b The UpSet plot displays the shared genes between DEGs in DRG after SNI and the marker genes that are highly enriched or expressed explicitly in different ST-spot clusters corresponding to different anatomical parts of the SC. c Violin plots illustrating the expression of 29 feature genes in each ST-spot cluster. These genes are uniquely overlapping between the DEGs in DRG and the marker genes specific to the SC_R8 spatial region but not to other clusters. d The spatial expression of the 29 genes as in c in SC connected to the injured peripheral nerve. e, f Immunofluorescence showing the expression of ATF3 in the DRG and SC 10 days after sham and SNL surgeries. Scale bars: 100 μm (e), 200 μm (f).

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