Fig. 3: Differential mRNA expression analysis in GC TME cell infiltration. | Communications Biology

Fig. 3: Differential mRNA expression analysis in GC TME cell infiltration.

From: Defining gastric cancer ecology: the crucial roles of TREM2+ macrophages and fibroblasts in tumor microenvironments

Fig. 3

A Volcano plot of gene expression differences in mRNA sequencing data between adjacent normal tissue samples and GC tissue samples (Normal, N = 3; GC, N = 3), with red points indicating significantly upregulated genes, blue points indicating significantly downregulated genes, and gray points indicating genes with no expression difference; B, C Bubble chart and bar graph of GO/KEGG enrichment analysis for highly expressed genes in the differential analysis, where the color of circles and bars represents the significance of enrichment, and the size of circles represents the number of enriched genes; D Gene Set Enrichment Analysis (GSEA) results showing the peaks and valleys represent the degree of dispersion between data; E EPIC analysis heatmap of cell types in adjacent normal tissue samples and GC tissue samples (Normal, N = 3; GC, N = 3); F Violin plot depicting the differential expression of various cell types adjacent to the tumor tissue. Quantitative data are presented as mean ± standard deviation and intergroup comparisons were performed using unpaired t-tests. * indicates P < 0.05 for comparison between two groups, ** indicates P < 0.01 for comparison between two groups; * denotes significance level.

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