Fig. 8: Impact of the CXC12/CXCR4 axis on tumor growth and metastasis in vivo. | Communications Biology

Fig. 8: Impact of the CXC12/CXCR4 axis on tumor growth and metastasis in vivo.

From: Defining gastric cancer ecology: the crucial roles of TREM2+ macrophages and fibroblasts in tumor microenvironments

Fig. 8

A–C Comparative analysis and quantitative assessment of tumor size and weight in xenograft tumors from each group (n = 8); D Evaluation of CD3 and CD8 expression in each group by immunohistochemical staining (scale bar: 50 μm); E Protein expression levels of Trem2, Cxcl12, and Cxcr4 in each group analyzed by Western blot; F Effects of GC metastasis on lung tissue in each group and quantitative analysis of metastatic nodules; G Histological changes in lung metastatic nodules evaluated by H&E staining and immunohistochemical staining for CD31 and CD206 (scale bar: 100 μm). Data are presented as mean ± standard deviation and intergroup comparisons were performed using unpaired t-tests. * denotes P < 0.05 for comparison between two groups, ** denotes P < 0.01, *** denotes P < 0.001, and ns indicates no statistical difference between the two groups. Statistical significance is indicated by *. Each group consists of 8 nude mice.

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