Fig. 5: Prediction of the target of QCT. | Communications Biology

Fig. 5: Prediction of the target of QCT.

From: Quercetin alleviates endothelial dysfunction in preeclampsia by inhibiting ferroptosis and inflammation through EGFR binding

Fig. 5

A PPI network of top ten targets of QCT. B–B3 The score of molecular docking of QCT with SRC, AKT1, and EGFR (B), and the representative images of molecular docking of QCT with SRC (B1), AKT1 (B2), and EGFR (B3). C–E Volcano plot of GSE114691 (C), GSE25906 (D), and GSE10588 (E) of differentially expressed genes (P value < 0.01) in placenta between control and PE patients. F Representative images of molecular docking of QCT with EGFR. G, H Representative Western blot images of cellular thermal shift assay (G) and the line graph of quantitative analysis of relative expressions of EGFR from the Control and QCT groups (H) (n = 6 per group of each temperature). The error bars in the figure represent means ± SD. ns no significance; **P < 0.01.

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