Fig. 7: Interactome of PfFBXO1 during schizogony and gametocytogenesis. | Communications Biology

Fig. 7: Interactome of PfFBXO1 during schizogony and gametocytogenesis.

From: PfFBXO1 is essential for inner membrane complex formation in Plasmodium falciparum during both asexual and transmission stages

Fig. 7

A Volcano-plot depicting the highly biotinylated proteins (in red) against the proteins identified in ~42 h.p.i. schizonts (compiled from 3 biological replicates). B Bubble plot representing the top 10 enriched Gene Ontology-based cellular component terms of the significantly biotinylated protein list in schizont stages. The enrichment analysis was performed using PlasmoDB. C Significantly biotinylated proteins (from 3 biological replicates) in stage III gametocytes represented by red in a volcano plot. D Top ten enriched categories within the GO-based cellular component analysis of the proteins significantly biotinylated in stage III gametocytes. The bait protein, PfFBXO1 and its known interactor PfSKP1 are highlighted in green. E Venn-diagram showing the overlap of the proteins identified by RIPA-based affinity MS/MS, triton X100-based affinity MS/MS in schizonts, and TurboID experiments in schizonts and stage III gametocytes.

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