Fig. 1: PDHB promotes HCC cells proliferation and invasion in vitro. | Communications Biology

Fig. 1: PDHB promotes HCC cells proliferation and invasion in vitro.

From: Isoacteoside alleviates hepatocellular carcinoma progression by inhibiting PDHB-mediated reprogramming of glucose metabolism

Fig. 1

A, F, G PDHB was either overexpressed or knocked down in HepG2 cells. B, H The CCK8 assay was conducted to evaluate the impact of PDHB overexpression or knockdown on HepG2 cell proliferation. C, I, J Colony formation assays were performed to assess the effect of PDHB overexpression or knockdown on the colony-forming capacity of HepG2 cells. D, K The Transwell assay was utilized to examine the influence of PDHB overexpression or knockdown on the invasion ability of HepG2 cells. Scale bar = 200 μm. E, L RT-PCR analysis was conducted to evaluate the effects of PDHB overexpression or knockdown on epithelial-mesenchymal transition (EMT) in HepG2 cells. Data are presented as means ± standard deviation from three independent experiments; *P < 0.05, **P < 0.01, ***P < 0.001.

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